Wednesday, November 29, 2006

Survey of technology facilitating kinase inhibitor development

All from the perspective of service companies not doing proprietary R & D.

Memorable quote:

"The focus on single purified kinase inhibitor screening has lead to poor efficacy in development, because of the ability of tumor cells to compensate and circumvent a block of a single node in the signaling network. Hence, there is a need for a systems biology approach to assay the activity of the signaling pathways downstream of the kinase targets," says Steve Horrigan, Ph.D., interim vp of research at Avalon Pharmaceuticals (

When added to the problem of genetic mutations, over the long term, can anyone beat the cancer's survival instincts?

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