Skewed towards rational DD, there's a few quotes worth repeating:
"Many scientists have realized that blindly screening millions of compounds in the lab and hoping for a hit or a lead is an irrational drug design process that rarely pays off,"
"HTS starts at approximately $1 million per project, with no guarantee you'll find anything useful. "
"Structure-guided design helps to localize subtle features and different conformations in the binding pocket."
"The protein kinases exemplify a family where the potential exists to accelerate lead discovery and optimization by inferring between the massive amount of structural and chemical data from gene family members."
Other takeaways:
AZ is working on CDK4
Wednesday, November 29, 2006
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